Negative regulation of fibroblast growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of fibroblast growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TACO1, SEMA4B, and HNMT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of fibroblast growth factor receptor signaling pathway activity versus TACO1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TACO1 →	-0.922	-0.302	<.001	.001	3	5
LUNG_NSCLC_LUAD	SEMA4B →	-1.645	-1.287	<.001	<.001	3	4
BREAST	HNMT →	-2.307	-1.311	.002	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	POLR2E →	-1.094	-0.318	.001	<.001	3	3
OESOPHAGUS	CAPZA1 →	-0.778	-1.292	.005	.006	3	3
UPPER_AERODIGESTIVE_TRACT	DAP3 →	-0.699	-0.302	.001	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040037 vs TACO1 — UPPER_AERODIGESTIVE_TRACT

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