Regulation of fibroblast growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of fibroblast growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEX46, KLF11, and CDCA4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEX46 grouped by Regulation of fibroblast growth factor receptor signaling pathway-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TEX46 →	+0.133	+0.933	.006	<.001	3	6
LUNG_NSCLC_LUAD	KLF11 →	-0.831	-0.813	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	CDCA4 →	-1.389	-0.950	.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	HSP90AA1 →	-1.591	-0.952	<.001	.001	3	4
LIVER	PLEK2 →	-3.176	-1.271	.001	<.001	3	4
LIVER	ABL2 →	-1.696	-1.397	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEX46 by Regulation of fibroblast growth factor receptor signaling pathway activity — SKIN

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