Regulation of fibroblast growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of fibroblast growth factor receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DMP1, RAC1, and RAB3GAP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DMP1 grouped by Regulation of fibroblast growth factor receptor signaling pathway-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DMP1 →	-0.370	-0.295	<.001	<.001	3	5
LUNG_SCLC	RAC1 →	+0.302	+0.175	.007	.004	3	5
BONE	RAB3GAP2 →	-0.374	-0.343	.002	<.001	3	4
BONE	RAB27A →	-0.371	-0.240	.002	.003	3	4
OVARY	ENY2 →	+0.275	+0.138	.006	.005	3	4
SKIN	LENG1 →	-0.195	-0.112	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DMP1 by Regulation of fibroblast growth factor receptor signaling pathway activity — BONE

Explore this box plot interactively →