Regulation of fibroblast growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of fibroblast growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ILF3, NEURL4, and AKAP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fibroblast growth factor receptor signaling pathway activity versus ILF3 in SOFT_TISSUE (Pearson r = -0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ILF3 →	-0.851	-0.267	.002	.002	3	6
BLOOD_Leukemia	NEURL4 →	-0.630	-0.433	.007	.009	3	6
LIVER	AKAP1 →	-1.565	-0.591	.007	.009	3	6
LUNG_NSCLC_LUSC	EXOSC5 →	-0.800	-0.465	.007	<.001	3	5
SOFT_TISSUE	SAFB →	-0.640	-0.256	.008	.004	3	5
SOFT_TISSUE	LEAP2 →	-0.831	-0.277	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040036 vs ILF3 — SOFT_TISSUE

Explore this scatter interactively →