snRNA modification

Across TCGA patient cohorts, RNA activity of the snRNA modification pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSIP1, RPRD1A, and HCFC1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA modification activity versus PSIP1 in BRCA (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PSIP1 →	+0.649	+0.028	<.001	<.001	3	8
OV	RPRD1A →	+0.452	+0.043	.003	<.001	3	7
UCEC	HCFC1 →	+0.161	+0.051	<.001	.007	3	7
BRCA	SMCHD1 →	+0.428	+0.032	<.001	<.001	3	7
BRCA	WRNIP1 →	+0.274	+0.023	<.001	<.001	3	7
BRCA	ORC3 →	+0.280	+0.024	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040031 vs PSIP1 — BRCA

Explore this scatter interactively →