snRNA modification

Across TCGA cell cohorts, RNA activity of the snRNA modification pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARPC2, SYNE1, and FAM160B1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA modification activity versus ARPC2 in BLOOD_Leukemia (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ARPC2 →	-0.529	-0.172	.004	<.001	3	6
LUNG_NSCLC_LUSC	SYNE1 →	-2.730	-0.436	.003	.007	3	5
LUNG_NSCLC_LUSC	FAM160B1 →	-1.130	-0.316	<.001	.003	3	5
LUNG_SCLC	VPS37A →	-0.547	-0.121	.002	.009	3	5
OESOPHAGUS	SEC22B →	-0.772	-0.197	<.001	.003	3	5
CNS	CPEB2 →	-1.621	-0.217	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040031 vs ARPC2 — BLOOD_Leukemia

Explore this scatter interactively →