Epigenetic regulation of gene expression

Across TCGA patient cohorts, RNA activity of the Epigenetic regulation of gene expression pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BRD3, HCFC1, and COG1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epigenetic regulation of gene expression activity versus BRD3 in GBM (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BRD3 →	+0.326	+0.037	<.001	<.001	3	7
GBM	HCFC1 →	+0.173	+0.027	<.001	<.001	3	7
OV	COG1 →	-0.185	-0.036	.007	.006	3	7
LSCC	ADNP →	+0.430	+0.042	<.001	<.001	3	7
LSCC	PBRM1 →	+0.344	+0.033	<.001	.003	3	7
GBM	RPL5 →	-0.295	-0.040	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040029 vs BRD3 — GBM

Explore this scatter interactively →