Epigenetic regulation of gene expression

Across TCGA cell cohorts, RNA activity of the Epigenetic regulation of gene expression pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBMX, ILF3, and MEX3A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epigenetic regulation of gene expression activity versus RBMX in BLOOD_Leukemia (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RBMX →	+0.535	+0.127	<.001	<.001	3	7
BREAST	ILF3 →	+0.660	+0.111	.003	.002	3	6
PANCREAS	MEX3A →	+1.812	+0.105	.005	.002	3	6
BLOOD_Leukemia	TMED3 →	-0.629	-0.104	<.001	<.001	3	6
LUNG_SCLC	SPRYD7 →	-0.811	-0.168	<.001	.001	3	6
SOFT_TISSUE	CBX2 →	+2.141	+0.149	.002	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040029 vs RBMX — BLOOD_Leukemia

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