Positive regulation of embryonic development

Across TCGA patient cohorts, RNA activity of the Positive regulation of embryonic development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCKAP1L, PRKCB, and PDE4C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of embryonic development activity versus NCKAP1L in UCEC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCKAP1L →	-0.738	-0.214	.008	.001	3	4
UCEC	PRKCB →	-0.731	-0.202	.001	.001	3	4
LUAD	PDE4C →	+0.106	+0.114	.005	.004	3	3
LUAD	DENND4C →	+0.301	+0.105	<.001	<.001	3	3
LUAD	VPS37B →	+0.267	+0.106	.002	.004	3	3
LUAD	ATL3 →	+0.299	+0.100	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040019 vs NCKAP1L — UCEC

Explore this scatter interactively →