Positive regulation of embryonic development

Across TCGA cell cohorts, RNA activity of the Positive regulation of embryonic development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMC6, ANO9, and PARP14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of embryonic development activity versus TMC6 in OVARY (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TMC6 →	-1.905	-0.200	.001	<.001	3	5
BREAST	ANO9 →	-1.839	-0.244	.001	<.001	3	5
BONE	PARP14 →	-3.605	-0.248	<.001	.001	3	5
LARGE_INTESTINE	THTPA →	+0.920	+0.191	<.001	.007	3	5
CNS	CCDC71 →	+0.522	+0.157	<.001	<.001	3	5
STOMACH	ZNF165 →	-1.675	-0.220	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040019 vs TMC6 — OVARY

Explore this scatter interactively →