Negative regulation of multicellular organism growth

Across TCGA patient cohorts, RNA activity of the Negative regulation of multicellular organism growth pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COPS3, ATP6V0E2, and CNGB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of multicellular organism growth activity versus COPS3 in UCEC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COPS3 →	+0.420	+0.796	.003	<.001	3	4
UCEC	ATP6V0E2 →	+0.751	+0.639	.002	.006	3	4
HNSC	CNGB1 →	-1.145	-0.389	<.001	<.001	3	4
LSCC	ZBP1 →	-0.956	-0.541	<.001	<.001	3	4
LSCC	CFAP36 →	+0.446	+0.526	<.001	<.001	3	4
LSCC	TLCD3A →	+0.522	+0.509	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040015 vs COPS3 — UCEC

Explore this scatter interactively →