Negative regulation of multicellular organism growth

Across TCGA cell cohorts, RNA activity of the Negative regulation of multicellular organism growth pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX13, MTFMT, and NDUFS7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SOX13 grouped by Negative regulation of multicellular organism growth-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SOX13 →	+1.021	+0.830	.004	.001	3	4
OESOPHAGUS	MTFMT →	+0.910	+1.324	.001	.001	3	4
CNS	NDUFS7 →	+0.595	+0.909	.005	.006	3	4
CNS	CMSS1 →	-0.727	-0.978	.001	.004	3	4
KIDNEY	RAPH1 →	-1.207	-1.038	<.001	.005	3	4
SOFT_TISSUE	CTNNAL1 →	-2.001	-1.579	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SOX13 by Negative regulation of multicellular organism growth activity — BREAST

Explore this box plot interactively →