Regulation of multicellular organism growth

Across TCGA cell cohorts, RNA activity of the Regulation of multicellular organism growth pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFA5, PLEKHA2, and PHLDA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDUFA5 grouped by Regulation of multicellular organism growth-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NDUFA5 →	+0.887	+1.782	.002	<.001	3	4
BLOOD_Lymphoma	PLEKHA2 →	-2.436	-1.547	.006	.002	3	4
SKIN	PHLDA2 →	+1.654	+0.967	.002	.001	3	4
LUNG_NSCLC_LUAD	TUSC2 →	+0.578	+0.926	.002	<.001	3	3
LUNG_NSCLC_LUAD	YPEL5 →	-0.606	-0.695	.003	.005	2	4
LUNG_NSCLC_LUAD	UBL3 →	-0.682	-0.684	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDUFA5 by Regulation of multicellular organism growth activity — BLOOD_Lymphoma

Explore this box plot interactively →