Regulation of multicellular organism growth

Across TCGA cell cohorts, RNA activity of the Regulation of multicellular organism growth pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHN1, OSBPL6, and MAP1A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of multicellular organism growth activity versus CHN1 in SKIN (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CHN1 →	-2.219	-0.257	<.001	<.001	3	7
BLOOD_Lymphoma	OSBPL6 →	-2.544	-0.332	<.001	<.001	3	7
LUNG_SCLC	MAP1A →	-1.889	-0.188	<.001	.001	3	6
LARGE_INTESTINE	REEP2 →	-1.961	-0.230	.002	<.001	3	5
BLOOD_Lymphoma	MAP3K12 →	-1.016	-0.248	.003	.003	3	5
LIVER	CYP27B1 →	-1.223	-0.268	.008	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040014 vs CHN1 — SKIN

Explore this scatter interactively →