Regulation of growth rate

Across TCGA patient cohorts, RNA activity of the Regulation of growth rate pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SH2D4A, GSR, and ZBTB7B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of growth rate activity versus SH2D4A in BRCA (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SH2D4A →	+0.408	+0.072	.002	<.001	3	7
COAD	GSR →	+0.264	+0.056	<.001	<.001	3	5
LSCC	ZBTB7B →	+0.322	+0.090	<.001	<.001	3	5
HNSC	S100A16 →	+0.480	+0.084	<.001	.002	3	5
LSCC	TRIM29 →	+1.295	+0.076	<.001	<.001	3	4
OV	CRABP2 →	+0.650	+0.078	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040009 vs SH2D4A — BRCA

Explore this scatter interactively →