Regulation of growth rate

Across TCGA cell cohorts, RNA activity of the Regulation of growth rate pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C6orf201, DDX59, and FERMT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C6orf201 grouped by Regulation of growth rate-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	C6orf201 →	+0.241	+1.235	.002	.007	3	4
LUNG_SCLC	DDX59 →	+0.742	+1.096	<.001	.001	3	3
BONE	FERMT1 →	-2.115	-1.898	.002	<.001	3	3
BONE	BICRAL →	+0.855	+1.965	.002	<.001	3	3
LUNG_SCLC	SENP6 →	+0.713	+0.857	<.001	.005	3	3
BONE	SPTBN1 →	+1.747	+1.956	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C6orf201 by Regulation of growth rate activity — BONE

Explore this box plot interactively →