Regulation of growth rate

Across TCGA cell cohorts, RNA activity of the Regulation of growth rate pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX8, PHKG2, and RPL30, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SOX8 grouped by Regulation of growth rate-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SOX8 →	-0.136	-0.151	.005	.001	3	4
OESOPHAGUS	PHKG2 →	-0.213	-0.414	.003	<.001	3	4
STOMACH	RPL30 →	+0.431	+0.402	.005	<.001	3	4
CNS	GNGT2 →	-0.171	-0.223	<.001	<.001	3	4
SKIN	ITGA5 →	+0.125	+0.141	.003	.003	3	3
LUNG_NSCLC_LUSC	HNRNPA3P1 →	-0.225	-0.419	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SOX8 by Regulation of growth rate activity — BLOOD_Leukemia

Explore this box plot interactively →