Regulation of growth rate

Across TCGA cell cohorts, RNA activity of the Regulation of growth rate pathway is significantly associated with the drug response of multiple features, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Methotrexate, Refametinib, and PD0325901, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Methotrexate grouped by Regulation of growth rate-low versus -high activity in OVARY.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Methotrexate →	-1.450	-1.647	.041	.001	1	1
OVARY	Refametinib →	+0.859	+1.647	.015	.001	1	1
OVARY	PD0325901 →	+1.495	+1.647	.007	.001	1	1
OVARY	Selumetinib →	+1.144	+1.647	.022	.001	1	1
OVARY	Trametinib →	+1.734	+1.647	<.001	.001	1	1
OVARY	SCH772984 →	+1.295	+1.647	.009	.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Methotrexate by Regulation of growth rate activity — OVARY

Explore this box plot interactively →