Viral RNA genome replication

Across TCGA cell cohorts, RNA activity of the Viral RNA genome replication pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP25, PIN1, and SLC2A12, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Viral RNA genome replication activity versus ARHGAP25 in CNS (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ARHGAP25 →	-0.901	-0.080	.001	.002	2	7
LARGE_INTESTINE	PIN1 →	+0.651	+0.085	.001	.009	2	6
OVARY	SLC2A12 →	-1.626	-0.111	.005	.005	3	5
STOMACH	PCLAF →	+1.274	+0.089	.001	.008	3	5
OVARY	PCMTD1 →	-1.036	-0.081	<.001	.008	3	5
OVARY	HNRNPF →	+0.750	+0.101	.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0039694 vs ARHGAP25 — CNS

Explore this scatter interactively →