Regulation of MDA-5 signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of MDA-5 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX58, DDX60, and IFI35, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of MDA-5 signaling pathway activity versus DDX58 in GBM (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DDX58 →	+0.721	+0.088	<.001	<.001	3	10
OV	DDX60 →	+0.623	+0.058	<.001	<.001	3	9
BRCA	IFI35 →	+0.416	+0.061	<.001	<.001	3	9
OV	NMI →	+0.459	+0.047	<.001	.006	3	9
GBM	OAS2 →	+1.026	+0.079	<.001	<.001	3	9
LSCC	IFIT3 →	+0.986	+0.072	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0039533 vs DDX58 — GBM

Explore this scatter interactively →