Regulation of MDA-5 signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of MDA-5 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZMAT5, RNLS, and CTAGE15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of MDA-5 signaling pathway activity versus ZMAT5 in OVARY (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ZMAT5 →	-0.771	-0.286	<.001	.002	3	4
BONE	RNLS →	+2.214	+0.331	.004	.002	3	4
LIVER	CTAGE15 →	+1.085	+0.455	.008	.001	3	4
SKIN	USF2 →	-1.151	-0.321	.005	.002	3	4
SKIN	HELB →	+0.390	+0.168	.001	.007	3	4
SKIN	YWHAH →	-0.863	-0.191	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0039533 vs ZMAT5 — OVARY

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