Regulation of cytoplasmic pattern recognition receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of cytoplasmic pattern recognition receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHST15, RTN4, and VASH1-AS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cytoplasmic pattern recognition receptor signaling pathway activity versus CHST15 in PDAC (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CHST15 →	+0.412	+0.138	.005	.007	2	5
CCRCC	RTN4 →	+0.337	+0.117	.002	.005	3	4
CCRCC	VASH1-AS1 →	-0.220	-0.143	<.001	<.001	3	4
UCEC	SCAMP4 →	+0.404	+0.124	.008	.005	3	4
BRCA	WDR90 →	-0.878	-0.199	<.001	<.001	3	4
OV	COL1A1 →	+2.396	+0.197	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0039531 vs CHST15 — PDAC

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