Regulation of cytoplasmic pattern recognition receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of cytoplasmic pattern recognition receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MFSD8, DLX1, and REEP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cytoplasmic pattern recognition receptor signaling pathway activity versus MFSD8 in BONE (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MFSD8 →	+0.783	+0.183	.005	.004	2	6
BLOOD_Lymphoma	DLX1 →	+0.796	+0.096	<.001	<.001	3	5
LARGE_INTESTINE	REEP2 →	+2.329	+0.130	<.001	.001	3	5
OESOPHAGUS	ANKRD6 →	+2.365	+0.192	<.001	<.001	3	5
STOMACH	MCRIP2 →	-1.155	-0.199	<.001	.009	3	5
BLOOD_Leukemia	TSPO →	-2.912	-0.139	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0039531 vs MFSD8 — BONE

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