MDA-5 signaling pathway

Across TCGA patient cohorts, RNA activity of the MDA-5 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SKCM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX58, DHX58, and OAS3, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, MDA-5 signaling pathway activity versus DDX58 in SKCM (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DDX58 →	+1.532	+0.102	<.001	<.001	3	34
UCS	DHX58 →	+1.654	+0.134	<.001	<.001	3	34
DLBC	OAS3 →	+2.319	+0.124	<.001	<.001	3	34
UCS	OAS2 →	+2.042	+0.124	<.001	<.001	3	34
SKCM	IFIH1 →	+1.840	+0.103	<.001	<.001	3	34
UVM	STAT1 →	+1.748	+0.064	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0039530 vs DDX58 — SKCM

Explore this scatter interactively →