MDA-5 signaling pathway

Across TCGA patient cohorts, RNA activity of the MDA-5 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ETV7, IFIH1, and NMI, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, MDA-5 signaling pathway activity versus ETV7 in OV (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ETV7 →	+1.649	+0.318	<.001	<.001	3	6
OV	IFIH1 →	+0.795	+0.202	<.001	<.001	3	6
COAD	NMI →	+0.685	+0.483	.002	.002	3	6
OV	XAF1 →	+0.927	+0.164	.001	.005	2	7
LSCC	IFI27 →	+1.863	+0.270	<.001	<.001	3	6
OV	OAS1 →	+1.607	+0.267	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0039530 vs ETV7 — OV

Explore this scatter interactively →