MDA-5 signaling pathway

Across TCGA cell cohorts, RNA activity of the MDA-5 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBGCP4, UBE4B, and CADM4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TUBGCP4 grouped by MDA-5 signaling pathway-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TUBGCP4 →	+0.996	+1.651	.001	.001	3	4
BREAST	UBE4B →	-0.629	-0.891	.001	.001	3	3
LIVER	CADM4 →	+1.806	+0.943	.009	.004	3	3
OESOPHAGUS	MICU1 →	+1.046	+1.417	<.001	<.001	3	3
OESOPHAGUS	CFP →	+0.182	+1.297	.005	<.001	3	3
OESOPHAGUS	GET1 →	+0.608	+1.262	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TUBGCP4 by MDA-5 signaling pathway activity — BLOOD_Myeloma

Explore this box plot interactively →