MDA-5 signaling pathway

Across TCGA cell cohorts, RNA activity of the MDA-5 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTG1, ALS2CL, and POU5F1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, MDA-5 signaling pathway activity versus BTG1 in BREAST (Pearson r = 0.94).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	BTG1 →	+1.044	+1.730	.001	<.001	3	2
OVARY	ALS2CL →	-3.860	-1.842	<.001	.006	1	3
LARGE_INTESTINE	POU5F1 →	-2.505	-1.721	.002	.001	2	2
LARGE_INTESTINE	SCAF1 →	+0.895	+1.585	.003	.003	2	2
LARGE_INTESTINE	RIMS2 →	+1.420	+1.721	.007	.001	2	2
LARGE_INTESTINE	CPNE7 →	-3.590	-1.721	<.001	.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0039530 vs BTG1 — BREAST

Explore this scatter interactively →