TORC2 signaling

Across TCGA patient cohorts, RNA activity of the TORC2 signaling pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERBP1, SORBS1, and STAB1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, TORC2 signaling activity versus SERBP1 in OV (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SERBP1 →	-0.331	-0.055	<.001	<.001	3	8
HNSC	SORBS1 →	+0.578	+0.059	<.001	<.001	3	7
BRCA	STAB1 →	+0.315	+0.034	.001	<.001	3	7
HNSC	TBCEL →	+0.239	+0.056	<.001	.001	3	7
GBM	CNRIP1 →	+0.448	+0.072	.001	<.001	3	7
HNSC	ANXA6 →	+0.425	+0.073	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038203 vs SERBP1 — OV

Explore this scatter interactively →