TORC2 signaling

Across TCGA patient cohorts, RNA activity of the TORC2 signaling pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V0E1, PARN, and PRELID2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, TORC2 signaling activity versus ATP6V0E1 in GBM (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ATP6V0E1 →	+0.392	+0.669	.003	.002	3	3
GBM	PARN →	+0.238	+0.622	<.001	.001	3	3
PDAC	PRELID2 →	+0.508	+0.614	<.001	<.001	3	3
UCEC	KCMF1 →	+0.235	+0.942	.007	<.001	3	3
CCRCC	LTBP2 →	-0.869	-0.644	.007	.001	3	2
CCRCC	UBE2L2 →	-0.613	-0.397	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038203 vs ATP6V0E1 — GBM

Explore this scatter interactively →