TORC2 signaling

Across TCGA cell cohorts, RNA activity of the TORC2 signaling pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNTF, DUS3L, and METTL3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CNTF grouped by TORC2 signaling-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CNTF →	-0.262	-0.486	<.001	.006	3	3
SKIN	DUS3L →	+0.240	+1.403	.004	<.001	3	3
OVARY	METTL3 →	-0.166	-1.609	.001	<.001	3	3
LUNG_SCLC	PRMT9 →	+0.213	+0.882	.006	.008	3	3
BONE	CDC20 →	+0.270	+0.258	.008	.001	2	4
BLOOD_Leukemia	PGM2L1 →	-0.175	-0.500	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CNTF by TORC2 signaling activity — BLOOD_Leukemia

Explore this box plot interactively →