Nerve growth factor signaling pathway

Across TCGA patient cohorts, RNA activity of the Nerve growth factor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL22RA1, SMPX, and QPRT, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nerve growth factor signaling pathway activity versus IL22RA1 in GBM (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IL22RA1 →	-0.179	-0.687	.006	<.001	3	3
LUAD	SMPX →	+0.562	+0.448	<.001	<.001	3	3
BRCA	QPRT →	+1.228	+0.372	<.001	.008	3	3
LSCC	MACORIS →	+0.273	+0.405	.006	.003	3	3
LSCC	CTSO →	+0.534	+0.514	.002	.009	3	3
CCRCC	TONSL-AS1 →	-0.332	-0.668	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038180 vs IL22RA1 — GBM

Explore this scatter interactively →