Nerve growth factor signaling pathway

Across TCGA cell cohorts, RNA activity of the Nerve growth factor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEBPB, SORT1, and ITGA5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nerve growth factor signaling pathway activity versus CEBPB in LUNG_SCLC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CEBPB →	-0.873	-0.366	<.001	.002	3	5
SKIN	SORT1 →	+2.360	+1.131	<.001	<.001	3	5
SKIN	ITGA5 →	-2.677	-0.948	<.001	<.001	3	5
SKIN	UBL3 →	+1.536	+1.138	.008	.006	3	5
OVARY	SORL1 →	+1.778	+0.617	.003	.005	3	4
OVARY	MTARC1 →	+1.795	+0.638	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038180 vs CEBPB — LUNG_SCLC

Explore this scatter interactively →