Neurotrophin signaling pathway

Across TCGA patient cohorts, RNA activity of the Neurotrophin signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1A_S2106, MAP1A_S2664, and SCAF11_S608, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotrophin signaling pathway activity versus MAP1A_S2106 in OV (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MAP1A_S2106 →	+0.514	+0.041	.001	.003	3	5
GBM	MAP1A_S2664 →	+0.588	+0.068	<.001	<.001	3	5
OV	SCAF11_S608 →	-0.425	-0.030	.009	.004	3	4
OV	IWS1_S440 →	-1.431	-0.052	.002	<.001	3	4
GBM	MRTO4 →	-0.307	-0.059	.001	<.001	3	4
COAD	SSNA1 →	-0.408	-0.028	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038179 vs MAP1A_S2106 — OV

Explore this scatter interactively →