Neurotrophin signaling pathway

Across TCGA patient cohorts, RNA activity of the Neurotrophin signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL1A1, SCN7A, and LRRC15, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotrophin signaling pathway activity versus COL1A1 in HNSC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	COL1A1 →	+1.161	+0.660	<.001	.002	3	3
HNSC	SCN7A →	+0.355	+0.616	.001	<.001	3	3
HNSC	LRRC15 →	+0.816	+0.560	.001	<.001	3	3
GBM	ATP6V0E2 →	+0.731	+0.691	<.001	<.001	3	3
GBM	KRT39 →	+0.144	+0.448	.003	.005	3	3
GBM	VTRNA2-2P →	+0.593	+0.503	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038179 vs COL1A1 — HNSC

Explore this scatter interactively →