Neurotrophin signaling pathway

Across TCGA cell cohorts, RNA activity of the Neurotrophin signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMP2, ACSF2, and UBTD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TIMP2 grouped by Neurotrophin signaling pathway-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TIMP2 →	+3.004	+1.008	<.001	.002	3	7
SOFT_TISSUE	ACSF2 →	+2.936	+1.441	.003	.003	3	6
BREAST	UBTD1 →	+1.085	+0.963	.001	<.001	3	6
CNS	ICAM1 →	+2.619	+1.009	.001	.002	3	5
SOFT_TISSUE	NR3C1 →	+3.018	+1.198	<.001	.005	3	5
LUNG_NSCLC_LUSC	TRAM2 →	+1.702	+1.609	.006	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TIMP2 by Neurotrophin signaling pathway activity — BREAST

Explore this box plot interactively →