Neurotrophin signaling pathway

Across TCGA cell cohorts, RNA activity of the Neurotrophin signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAPGEF2, SOS1, and HEATR5B, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotrophin signaling pathway activity versus RAPGEF2 in BLOOD_Lymphoma (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	RAPGEF2 →	+2.061	+0.110	<.001	<.001	3	13
BLOOD_Lymphoma	SOS1 →	+0.756	+0.085	<.001	<.001	3	12
LARGE_INTESTINE	HEATR5B →	+0.748	+0.120	<.001	<.001	3	9
BREAST	CAMK2D →	+1.844	+0.091	<.001	.004	3	8
BLOOD_Lymphoma	PDCD4 →	+1.531	+0.082	.004	<.001	3	8
STOMACH	LCOR →	+0.955	+0.156	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038179 vs RAPGEF2 — BLOOD_Lymphoma

Explore this scatter interactively →