Neurotrophin signaling pathway

Across TCGA cell cohorts, RNA activity of the Neurotrophin signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AVPI1, IGFBP6, and TMEM131L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotrophin signaling pathway activity versus AVPI1 in URINARY_TRACT (Pearson r = -0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	AVPI1 →	-1.348	-1.296	<.001	.001	3	5
SKIN	IGFBP6 →	-2.840	-1.590	.002	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	TMEM131L →	+0.782	+0.642	.006	.001	3	5
SKIN	TGFBI →	-5.190	-1.303	<.001	<.001	3	5
BLOOD_Lymphoma	IL9R →	+0.978	+1.203	.005	<.001	3	5
CNS	NGFR →	-2.830	-0.640	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038179 vs AVPI1 — URINARY_TRACT

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