Interleukin-17A-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-17A-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LENG8_S351, RPL5, and LIMA1_S365, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-17A-mediated signaling pathway activity versus LENG8_S351 in LUAD (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LENG8_S351 →	-0.403	-0.039	<.001	<.001	3	6
LSCC	RPL5 →	-0.196	-0.071	<.001	<.001	3	6
OV	LIMA1_S365 →	+0.496	+0.036	.006	.003	3	5
BRCA	UBE2S →	-0.488	-0.035	<.001	<.001	3	5
LUAD	DDX21_S89 →	-0.823	-0.054	<.001	<.001	3	5
UCEC	ARFIP1 →	+0.349	+0.088	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038173 vs LENG8_S351 — LUAD

Explore this scatter interactively →