Interleukin-17A-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-17A-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRP11, CFAP251, and ZFP90, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-17A-mediated signaling pathway activity versus LRP11 in HNSC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LRP11 →	+0.446	+0.828	<.001	<.001	3	3
HNSC	CFAP251 →	+0.495	+0.712	.004	.001	3	3
UCEC	ZFP90 →	+0.312	+0.463	.005	.001	3	3
UCEC	RNU6-26P →	+0.730	+0.540	<.001	.002	3	3
UCEC	MINCR →	+0.427	+0.530	.003	.009	3	3
PDAC	PPP1R13L →	+0.461	+0.821	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038173 vs LRP11 — HNSC

Explore this scatter interactively →