Interleukin-17A-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Interleukin-17A-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CIAO2B, PLK3, and ATG101, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CIAO2B grouped by Interleukin-17A-mediated signaling pathway-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CIAO2B →	+0.658	+1.094	.008	.006	3	6
SKIN	PLK3 →	+1.160	+1.434	.003	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	ATG101 →	+0.772	+1.751	<.001	<.001	3	4
LARGE_INTESTINE	MADD →	-0.713	-0.900	.004	.006	3	4
BREAST	APOM →	-0.822	-1.113	.001	.002	3	4
KIDNEY	SEMA4F →	+0.834	+1.157	.004	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CIAO2B by Interleukin-17A-mediated signaling pathway activity — LUNG_SCLC

Explore this box plot interactively →