Interleukin-33-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-33-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGAP25, IL33, and LAT_S224, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-33-mediated signaling pathway activity versus ARHGAP25 in GBM (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGAP25 →	+0.508	+0.081	<.001	.003	3	7
LSCC	IL33 →	+0.631	+0.093	<.001	<.001	3	6
LUAD	LAT_S224 →	+0.761	+0.076	<.001	<.001	3	6
LUAD	MAIP1 →	-0.306	-0.063	<.001	<.001	3	6
LSCC	ARHGDIB →	+0.401	+0.074	<.001	<.001	3	6
LSCC	AFG3L2 →	-0.477	-0.077	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038172 vs ARHGAP25 — GBM

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