Interleukin-33-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-33-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANGPTL6, PDE7B, and LYN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-33-mediated signaling pathway activity versus ANGPTL6 in GBM (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ANGPTL6 →	+0.399	+0.133	.001	.009	3	4
GBM	PDE7B →	+0.714	+0.132	.002	.006	3	4
BRCA	LYN →	+0.587	+0.147	<.001	<.001	3	4
BRCA	CXCR5 →	+0.093	+0.146	.002	.001	3	4
UCEC	ODCP →	+0.437	+0.227	.003	.005	3	3
GBM	NES →	+0.649	+0.112	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038172 vs ANGPTL6 — GBM

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