Interleukin-33-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Interleukin-33-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SELENOW, UHMK1, and ZNF264, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-33-mediated signaling pathway activity versus SELENOW in BLOOD_Lymphoma (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SELENOW →	+3.731	+0.430	<.001	.002	3	4
CNS	UHMK1 →	+0.993	+0.648	.001	.002	2	5
CNS	ZNF264 →	+0.941	+0.534	.001	.004	3	4
CNS	ARAP2 →	+1.351	+0.671	<.001	<.001	3	3
SKIN	SPTBN2 →	-2.050	-0.523	<.001	.008	3	3
OVARY	ECSCR →	+6.125	+0.564	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038172 vs SELENOW — BLOOD_Lymphoma

Explore this scatter interactively →