Somatostatin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Somatostatin receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NNMT, MCF2L, and C2CD5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Somatostatin receptor signaling pathway activity versus NNMT in GBM (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NNMT →	-1.077	-0.523	<.001	.002	3	5
CCRCC	MCF2L →	+0.416	+0.835	<.001	<.001	3	5
GBM	C2CD5 →	+0.206	+0.644	<.001	<.001	3	5
GBM	SPTBN1 →	+0.280	+0.413	<.001	.007	3	5
GBM	BCAT1 →	-0.605	-0.624	.006	.003	3	5
UCEC	MAGED1 →	-0.309	-0.724	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038169 vs NNMT — GBM

Explore this scatter interactively →