Somatostatin receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Somatostatin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNNI1, RBM4, and CTSL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TNNI1 grouped by Somatostatin receptor signaling pathway-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TNNI1 →	-0.517	-1.184	.001	.002	3	5
STOMACH	RBM4 →	-0.706	-1.283	<.001	.004	3	4
BONE	CTSL →	+3.158	+1.224	.002	.003	2	5
LARGE_INTESTINE	SLC2A6 →	+1.330	+0.938	<.001	<.001	3	4
LARGE_INTESTINE	SLC9A7 →	+1.342	+1.078	.006	.001	3	4
BLOOD_Leukemia	BCL7A →	-2.067	-1.196	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TNNI1 by Somatostatin receptor signaling pathway activity — LARGE_INTESTINE

Explore this box plot interactively →