Thrombopoietin-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Thrombopoietin-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNHG21, LRIG3, and IQCE, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thrombopoietin-mediated signaling pathway activity versus SNHG21 in COAD (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SNHG21 →	+0.292	+0.185	.001	.001	3	4
LSCC	LRIG3 →	-0.632	-0.285	.004	.005	3	3
HNSC	IQCE →	-0.366	-0.212	.002	.005	3	3
HNSC	RPSAP15 →	+0.424	+0.216	.006	.004	3	3
BRCA	CLEC5A →	-0.789	-0.199	.001	.003	3	3
BRCA	ATG12P1 →	-0.560	-0.210	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038163 vs SNHG21 — COAD

Explore this scatter interactively →