Thrombopoietin-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Thrombopoietin-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AXL, ZNF503, and FOSL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AXL grouped by Thrombopoietin-mediated signaling pathway-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	AXL →	-5.146	-1.303	.003	.003	3	5
KIDNEY	ZNF503 →	-1.153	-1.030	.001	.001	3	5
BONE	FOSL1 →	-5.597	-1.667	<.001	<.001	3	5
BONE	PDCD1LG2 →	-2.824	-1.654	<.001	<.001	3	5
BONE	TNFRSF12A →	-5.424	-1.652	<.001	<.001	3	5
BONE	PVR →	-1.500	-1.052	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AXL by Thrombopoietin-mediated signaling pathway activity — BONE

Explore this box plot interactively →