Thrombopoietin-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Thrombopoietin-mediated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G1B, CBX2, and ABO, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLA2G1B grouped by Thrombopoietin-mediated signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PLA2G1B →	-0.250	-1.704	<.001	<.001	3	1
BLOOD_Leukemia	CBX2 →	+0.210	+1.663	<.001	<.001	3	1
BLOOD_Leukemia	ABO →	+0.140	+1.704	<.001	<.001	3	1
BLOOD_Leukemia	CD19 →	+0.316	+1.704	.003	<.001	3	1
BLOOD_Leukemia	RNF186 →	+0.246	+1.704	.003	<.001	3	1
BLOOD_Leukemia	SLC9A9 →	+0.146	+1.704	.006	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLA2G1B by Thrombopoietin-mediated signaling pathway activity — BLOOD_Leukemia

Explore this box plot interactively →