C-X-C chemokine receptor CXCR4 signaling pathway

Across TCGA patient cohorts, RNA activity of the C-X-C chemokine receptor CXCR4 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF782, ASH1L-IT1, and NNT-AS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, C-X-C chemokine receptor CXCR4 signaling pathway activity versus ZNF782 in COAD (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ZNF782 →	-0.232	-0.452	.007	.003	3	4
LSCC	ASH1L-IT1 →	-0.389	-0.420	.008	.005	3	4
LSCC	NNT-AS1 →	-0.600	-0.400	.004	.006	2	5
BRCA	FSD1L →	-0.595	-0.348	<.001	.001	3	4
PDAC	NAV2-AS2 →	-0.273	-0.307	<.001	.009	3	3
COAD	ANKRD26 →	-0.188	-0.419	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038159 vs ZNF782 — COAD

Explore this scatter interactively →