C-X-C chemokine receptor CXCR4 signaling pathway

Across TCGA patient cohorts, RNA activity of the C-X-C chemokine receptor CXCR4 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STX10_S134, CYBB, and NUFIP2_S214, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, C-X-C chemokine receptor CXCR4 signaling pathway activity versus STX10_S134 in HNSC (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	STX10_S134 →	-1.283	-0.882	<.001	.002	3	3
CCRCC	CYBB →	+0.475	+0.532	<.001	<.001	3	3
GBM	NUFIP2_S214 →	+0.585	+0.930	<.001	<.001	3	3
OV	FOXO3_S284 →	-0.928	-0.749	.003	<.001	2	4
OV	PPP1R9A_S184 →	+1.307	+0.816	<.001	.002	3	3
OV	SGPP1_S112 →	+0.329	+0.440	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038159 vs STX10_S134 — HNSC

Explore this scatter interactively →